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Whipple disease

Whipple disease is a rare bacterial infection that most often affects your joints and digestive system. Whipple disease interferes with normal digestion by impairing the breakdown of foods, such as fats and carbohydrates, and hampering your body's ability to absorb nutrients Whipple's disease prevents your body from properly absorbing nutrients. Because of this, it affects many different parts of the body and is associated with a variety of symptoms Whipple's disease was first recognized in 1907 by George Hoyt Whipple. The case centered on a man who had problems with weight loss, arthritis, chronic cough, and fever.More than a century later. Dutly F, Altwegg M. Whipple's disease and Tropheryma whippelii. Clin Microbiol Rev 2001; 14: 561-83. Dumler JS, Baisden BL, Yardley JH, Raoult D. Immunodetection of Tropheryma whipplei in intestinal tissues from Dr. Whipple's 1907 patient

Whipple's disease - Symptoms and causes - Mayo Clini

  1. Materiale og metode. Artikkelen er basert på ikke-systematiske litteratursøk i PubMed (fra januar 2007 og uten tidsbegrensning bakover i tid) på søkeordene «Whipple's disease», som kombinert med «Tropheryma whippelii» ga 118 treff og kombinert med «Tropheryma whipplei» 65 treff
  2. Whipple disease is a rare infectious multisystem disorder caused by the actinobacteria Tropheryma whipplei. Epidemiology The incidence of Whipple disease is not truly known, one Swiss study estimated it at approximately 1 per 1.5 million per ye..
  3. Ved Whipples operasjon fjernes bukspyttkjertelens hode-region. Ettersom bukspyttkjertelen har felles blodforsyning og lymfedrenasje med nærliggende organer, fjernes en del av galleveiene, hele tolvfingertarmen og ofte nederste del av magesekken. Til slutt gjøres en rekonstruksjon, der tynntarmen skjøtes til gjenværende gallegang-, magesekk- og bukspyttkjertelrest. Whipples operasjon.
  4. Whipples operasjon, pankreatoduodenektomi, er en operasjonsmetode som gjennomføres ved sykdommer i selve bukspyttkjertelen (i pankreashodet) eller i området rundt
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  6. Whipple disease is an infectious bacterial disease that affects many different organ systems and interferes with the body's ability to process (metabolize) fats. The disease usually occurs in the gastrointestinal system, but may affect any part of the body including the heart, lungs, brain, joints, and eyes. [2
  7. Whipple disease is not transmitted from person to person; Some people may be more likely to develop Whipple disease because of genetic factors—related to genes, or traits passed from parent to child—that influence the body's immune system

Whipple disease is a rare disease resulting from bacterial infection that leads to inadequate absorption of nutrients (malabsorption) from the intestine. It is believed to result from infection with bacteria known as Tropheryma whippelii. The infection usually involves the small intestine, but over. Whipple disease is an infectious bacterial intestinal disease. It commonly causes diarrhea and weight loss. If the central nervous system is affected, it can be deadly. Treatment is with antibiotics In 2000, Tropheryma whipplei was finally identified as the cause of Whipple's disease, a chronic condition with protean manifestations that was first described in 1907. This review discusses the ep.. Whipple's disease is a rare, chronic, systemic infectious disorder with prominent intestinal manifestations. It presents with weight loss, arthralgia, diarrhea, and abdominal pain. There are different entities of infection or carriage, respectively, classical Whipple's disease, localized WD, and Iso

Diarrhea Causes at Florida Atlantic University - StudyBlue

Whipple disease is a rare condition that mainly affects the small intestine. This prevents the small intestines from allowing nutrients to pass into the rest of the body. This is called malabsorption. Causes. Whipple disease is caused by infection with a form of bacteria called Tropheryma whipplei. The disorder mainly affects white men of. 1. Curr Opin Gastroenterol. 2008 Mar;24(2):141-8. doi: 10.1097/MOG.0b013e3282f3f4f1. Whipple disease. Marth T(1), Schneider T. Author information: (1)St Josef Hospital, Zell/Mosel, Germany bMedical department I, Charité - University Medicine Berlin, CBF, Berlin, Germany. t.marth@krankenhaus-zell.de PURPOSE OF REVIEW: The availability of and advantages in molecular technology and immunology. Whipple disease is a rare condition that mainly affects the small intestine. This prevents the small intestine from allowing nutrients to pass into the rest of the body. This is called malabsorption

Whipple disease is a rare, multisystemic, chronic infectious disease caused by Tropheryma whipplei, a gram-positive bacterium from the Actinomycetes clade with a genome rich in guanine and cytosine (G-C) nucleotides. Raoult D, Ogata H, Audic S, et al. Tropheryma whipplei twist: a human pathogenic Actinobacteria with a reduced genome Whipple disease is a very rare infectious disease that affects many organ systems of the body. Less than a thousand cases have been reported worldwide and it has an annual incidence of less than one in a million. The disease is named after George Hoyt Whipple who described the first case in 1907 [1]

Whipple's Disease: Symptoms, Causes, and Treatment

  1. Pathophysiology of Whipple disease. Diagnosis. PCR, immunohistochemistry, PAS stain (PAS+ diastase resistant) Case reports. 47 and 50 year old men with malabsorption (Case of the Week #303) Treatment. Antibiotics Relapses are common Gross description. Shaggy mucosa, edematous bowel wal
  2. Whipple disease is a rare multi-system infectious bacterial disease that interferes with your body's ability to metabolize fats. Whipple disease is caused by the bacterium Tropheryma whipplei, the disorder can affect any system in the body, including the brain, eyes, heart, joints, and lungs, but usually occurs in the gastrointestinal system primarily affects the small intestine
  3. Whipple disease is rare, and the signs and symptoms can indicate other, more common disorders, so it can be hard to diagnose. As a result, it's often diagnosed in its later stages. However, an early diagnosis reduces the risk of serious health risks associated with not treating the condition
  4. al cramping and pain, weight loss, fatigue and weakness, inflamed joints like the ankles, knees and wrist
  5. Whipple's disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. Caused by the bacterium Tropheryma whipplei , the disorder can affect any system in the body, including the brain, eyes, heart, joints, and lungs, but usually occurs in the gastrointestinal system
  6. Fenollar F, Puechal X, Raoult D; Whipple's disease.N Engl J Med. 2007 Jan 4356(1):55-66. Desnues B, Ihrig M, Raoult D, et al; Whipple's disease: a macrophage disease.Clin Vaccine Immunol. 2006 Feb. Deriban G, Marth T; Current concepts of immunopathogenesis, diagnosis and therapy in Whipple's Curr Med Chem. 200613(24):2921-6.. Schneider T, Moos V, Loddenkemper C, et al; Whipple's disease: new.
  7. Whipple病又称惠普尔病,即肠源性脂肪代谢障碍,是一种罕见的慢性感染性疾病。受累器官常见的有消化系统、关节,病程发展还可累及心脏、肺、大脑以及眼等

Whipples operasjon (pankreatoduodenektomi) gjøres ved mistanke om maligne svulster i bukspyttkjertelens hode-region, eller i nærliggende organer som tolvfingertarm eller nedre galleveier Whipple disease predominately affects white men aged 30 to 60. Although it affects many parts of the body (eg, heart, lung, brain, serous cavities, joints, eye, gastrointestinal tract), the mucosa of the small bowel is almost always involved Definition. Whipple's disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. Caused by the bacterium Tropheryma whipplei, the disorder can affect any system in the body, including the brain, eyes, heart, joints, and lungs, but usually occurs in the gastrointestinal system.Neurological symptoms occur in up to 40 percent of.

Whipple's Disease: Symptoms, Causes, Treatment, and Mor

Whipples sykdom - NHI

Whipples sykdom Tidsskrift for Den norske legeforenin

Whipple's disease is a systemic condition characterized by diarrhea, intestinal malabsorption, abdominal pain, lymphadenopathy, and a polyarthritis, which may antedate the other symptoms by several years. In the first forty-two years after Whipple's original description of this disease in 1907 (10), only ten references to it could be found in the English literature, but more recently it has. Whipple disease is a treatable, multisystem disease caused by infection with Tropheryma whipplei. Primarily considered a gastrointestinal disorder, the organism also invades joints, heart, skin, eyes, and the endocrine and nervous system. Rarely, Whipple disease of the brain may occur as a primary neurologic disorder without multisystem. Whipple disease is a systemic disease most likely caused by a gram-positive bacterium, Tropheryma whippelii. Although the first descriptions of the disorder described a malabsorption syndrome with small intestine involvement, the disease also affects the joints, central nervous system, and cardiovascular system Whipple Disease. Lucy Liu 0 % Topic. Review Topic. 0. 0. N/A. N/A. Questions. 0 2. 0. 0. 100 % 0 % Evidence. 0 1. 0. 0. 100 % 0 % Videos. 0 1. Snapshot: A 60-year-old Caucasian man presents to the emergency room with his family for fever and recent onset of dementia. His MMSE score was 20 at his last appointment with his primary care provider

Whipple disease Radiology Reference Article

Whipple’s Disease

Whipples operasjon - Kreftle

Whipple's disease, or intestinal lipodystrophy, is a systemic infectious disorder affecting mostly middle-aged white men. Patients present with weight loss, arthralgia, diarrhoea, and abdominal pain. The disease is commonly diagnosed by small-bowel biopsy; the appearance of the sample is characterised by inclusions in the lamina propria staining with periodic-acid-Schiff, which represent the. Whipple's disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei. Whipple's disease primarily causes malabsorption but may affect any part of the body. Weight loss, diarrhea, joint pain, and arthritis are common presenting symptoms. Whipple's disease is significantly more common in men Description. Whipple's disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. Caused by the bacterium Tropheryma whipplei, the disorder can affect any system in the body, including the brain, eyes, heart, joints, and lungs, but usually occurs in the gastrointestinal system THE DISEASE. Whipple's disease is considered a rare pathology, with less than 1,000 cases having been reported to date. In postmortem studies, the frequency of the disease is quoted as being less than .1%17.Males are more frequently affected than females60.Indeed, 80% of the cases occur in males

Whipples operasjon - Store medisinske leksiko

Whipple disease constitutes a rare, relapsing, slowly progressive, infectious, systemic illness characterized by fever of unknown origin, polyarthralgias, and chronic diarrhea. Other manifestations include skin and ocular involvement (ie, uveitis, retinitis, optic neuritis); generalized lymphadenopathy; afebrile, blood culture-negative endoc.. Whipple's Disease is a rare infectious gastrointestinal disorder. The incidence of this disease is 1 case per million people. It is not contagious and cannot be transmitted from one person to another. The disease may involve any organ system of the

Whipple's disease is a multi-system, infectious disease predominantly affecting the gastrointestinal tract and joints, with occasional involvement of the CNS. Because the causative bacterium, Tropheryma whipplei , has only recently been identified and cultured, 54 and because routine CSF findings in this disorder are nonspecific, 55 a laboratory diagnosis of CNS Whipple's disease rests on CSF. Whipple disease predominately affects white men aged 30 to 60. Although it affects many parts of the body (eg, heart, lung, brain, serous cavities, joints, eye, gastrointestinal tract), the mucosa of the small bowel is almost always involved. Affected patients may have subtle defects of cell. Whipple GH. A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acid in the intestinal and mesenteric lymphatic tissues. Bulletin of the Johns Hopkins Hospital. 1907;18:382-393. Paulley JW. A case of Whipple's disease (intestinal lipodystrophy). Gastroenterology. 1952; 22(1): 128-133; Haubrich WS Whipple's disease is named after George Hoyt Whipple who identified it in 1907. It is a rare systemic illness and is caused by infection of T. whippelii. The first symptom of infection is joint pain. Much later diarrhea and malabsorption follow. Without proper antibiotic treatment, death is likely within one year. Epidemiology of Whipple's. Whipple disease may appear as a primary neurological disorder in rare cases. It is rarely found as a cause of progressive neurological deterioration in patients. It has been suggested that neurological involvement will eventually occur in all patients with Whipple disease. However, only 10-20% of Whipple disease patients develop neurological.

Pathology Outlines - Whipple diseaseWhipple disease PAS stain | Spijsvertering

Whipple's Disease - UpToDat

  1. Whipple's Disease is listed as a rare disease by the Office of Rare Diseases (ORD) of the National Institutes of Health (NIH). This means that Whipple's Disease, or a subtype of Whipple's Disease, affects less than 200,000 people in the US population
  2. Whipple Disease Treatment. The condition can be treated with antibiotic therapy. If left untreated, Whipple's disease may ultimately turn to be fatal. Patients of Whipple disease need to be treated with antibiotics for a long time in order to cure the infections of central nervous system and the brain
  3. The Whipple procedure has a success rate of up to 70 to 80 percent as a treatment for cancer. The complication rate is 30 to 40 percent. However, the mortality rate is less than one percent. Patients usually have an increase in their average life expectancy after undergoing Whipple surgery
  4. Whipple disease is a rare bacterial infection that primarily affects the small intestine.The infection may spread to any organ in the body; however, it more commonly affects the. joints; central nervous system, which includes the brain, the spinal cord, and nerves located throughout the body; heart; eyes; lungs; Left untreated, Whipple disease gets worse and is usually life threatening...
  5. Whipple's disease is rare—since its first description less than 1000 cases have been reported in the literature which is certainly an underestimate of all cases. Men are affected much more often than women (over 80%) and the mean age of onset approaches 50 although the age range extends from childhood to senility

Whipple disease Genetic and Rare Diseases Information

  1. a propria; caused by Tropheryma whippleii . May lead to progressive malnutrition, dementia, and if untreated, death
  2. Whipple disease is caused by infection with a form of bacteria called Tropheryma whipplei. The disorder mainly affects white men of middle-age. Whipple disease is very rare. Risk factors are not known
  3. g arthritis is frequently an initial complaint. Gastrointestinal and general symptoms include marked diarrhoea (with serious malabsorption), abdo
  4. Dr. Carlo Oller, emergency physician, talks about whipple's disease
  5. Whipple's disease Intestinal lipodystrophy, lipodystrophy GI disease A systemic malabsorption syndrome characterized by diffuse tissue infiltration with glycoprotein-rich macrophages and abundant bacillary forms Clinical ♂:♀ ratio, 10:1, accompanied by acropachyia digestiva, cutaneous hyperpigmentation, malabsorption, diarrhea, steatorrhea, arthritis, lymphadenopathy, endocarditis, fever.
  6. Schwartzman S, Schwartzman M. Whipple's disease. Rheum Dis Clin North Am. 2013 May;39(2):313-21; Arnold CA, Moreira RK, Lam-Himlin D, De Petris G, Montgomery E. Whipple disease a century after the initial description: increased recognition of unusual presentations, autoimmune comorbidities, and therapy effects. Am J Surg Pathol. 2012 Jul;36(7.
  7. Whipple's disease is a disease which can affect any system of the body. However it mostly affects the small intestine. It is a bacterial disease in which the villi (protrusions from the wall of the small intestine) which help with the absorption of the nutrients are destroyed. Whipple's disease can affect other organs as well. Whipple's.

Whipple Disease NIDD

Whipple's disease can be treated but if it is not diagnosed it can be fatal. If it is diagnosed early enough it can be treated successfully with long courses of antibiotics. You will usually be taking antibiotics for at least twelve months or longer in order to kill the bacteria that are involved in causing this rare medical condition Whipple shield, a type of hypervelocity impact shield; See also. Whipple's disease, a rare bacterial disease (first described by George Whipple) Whipple procedure, surgical removal of pancreatic cancer (devised by Allen Whipple) Whipple's triad, conditions necessary for proving a diagnosis of hypoglycemia (by Allen Whipple Whipple's disease is a multi-system infectious bacterial disease that interferes with the body's ability to metabolize fats. The disorder can affect any system in the body, including the central nervous system, but usually occurs in the gastrointestinal system. Gastrointestinal symptoms may include diarrhea, weight loss, fatigue, weakness, and abdominal bleeding and pain

Whipple Disease - NORD (National Organization for Rare

Whipple disease synonyms, Whipple disease pronunciation, Whipple disease translation, English dictionary definition of Whipple disease. Whipple's disease. Translations. English: Whipple's disease n. enfermedad de Whipple, trastorno causado por la acumulación de depósitos Developed by renowned radiologists in each specialty, STATdx provides comprehensive decision support you can rely on - Whipple Disease Whipple's disease is a malabsorption illness. It interferes with the body's ability to absorb certain nutrients. The disease causes weight loss, incomplete breakdown of carbohydrates or fats, and malfunctions of the immune system, and it may affect the heart, lungs, brain, and eyes. When recognized and treated, Whipple's disease can usually be cured Whipple disease is caused by an infection with the organism Tropheryma whipplei. The infection almost always affects the small intestine but can affect other organs, such as the heart, lungs, brain, joints, and eyes

Treatment of Whipple's Disease. Once Whipple's disease is diagnosed, the treatment is with antibiotics, even in the absence of symptoms, it is desirable to use antibiotics that cross the blood-brain barrier. A recommended regimen is Ceftriaxone two grams a day for two weeks, followed by trimethoprim twice a day 160 mg-sulfamethoxazole 800 mg Whipple disease, a chronic multisystem disease caused by infection with T whipplei, was first described in 1907 by George H. Whipple who noted the presence of rod-shaped organisms in the vacuoles of foamy macrophages in the intestinal tissue of a 36-year-old man during autopsy. Over 40 years later, these cells were found to stain positively with PAS and, in 1961, electron microscopy. Whipple disease is a systemic disease most likely caused by a gram-positive bacterium, Tropheryma whipplei (formerly T whippelii). [1, 2] Although the first descriptions of the disorder described. Whipple's disease is a rare, chronic, systemic illness first described in a 36-year-old physician by George Whipple in 1907 ().Whipple named the disorder intestinal lipodystrophy based on his belief that altered fat metabolism played a role in its pathogenesis

whipple disease - Google Search | Whipple's disease, Medicine

Whipple's Disease Lymphadenopathy is the inflammation and enlargement of lymph nodes due to underlying Whipple's Disease, a rare infection that is caused by the bacterium Tropheryma whipplei The infection can affect different parts of the body, such as the joints, brain, lung, eyes, heart, and other regions Ophthalmic Whipple's Disease Definition. Whipple's disease is rare, multivisceral, and chronic, whose clinical presentation is typically dominated by a symptom triad of diarrhea, weight loss and malabsorption. However, digestive symptoms are often preceded for months or years by other symptoms, the mos Whipple Disease. Lucy Liu 0 % Topic. Review Topic. 0. 0. N/A. N/A. Questions. 2 2. 0. 0. 0 % 0 % Evidence. 1 1. 0. 0. 0 % 0 % Videos. 1 1. Snapshot: A 56-year-old Caucasian man with a history of nonspecific arthritis complains of chronic GI upset. He has had diarrhea almost daily for several months now

Introduction. George Whipple initially reported the disease bearing his name in 1907, in which he described a 36-year-old male medical missionary with an illness characterized by weight loss and intractable diarrhea (Whipple, 1907).However, extragastrointestinal manifestations were recognized from the first descriptions of this illness as well as in subsequent reports La malattia di Whipple è una rara malattia descritta per la prima volta dal patologo George Whipple (Johns Hopkins Hospital, U.S.A.) nel 1907. Il quadro era quello di un malassorbimento severo. L'esame istologico rivelava presenza nei linfonodi (ingranditi, specie mesenterici), nel tratto intestinale e in altri tessuti, di macrofagi PA Whipple disease is the result of a rare bacterial infection that damages the lining of the small intestine, resulting in malabsorption, and may involve other organs of the body. Other common symptoms are fever, loss of appetite, fatigue and weakness caused by anemia, cough, and pain when breathing. Lymph nodes - not lymphoma - Whipple disease

Whipples sykdom er en sjelden, systemisk smittsom sykdom forårsaket av bakterien Tropheryma whipplei.Først beskrevet av George Hoyt Whipple i 1907 og ofte betraktet som en gastrointestinal lidelse, forårsaker Whipples sykdom først og fremst malabsorpsjon, men kan påvirke alle deler av kroppen inkludert hjerte, hjerne, ledd, hud, lunger og øyne. . Vekttap, diaré, leddsmerter og leddgikt. Whipple's is a rare multisystem disease, often with a long prodrome. It has variable symptomology, caused by invasion of various tissues by T whipplei and their subsequent incorporation by tissue macrophages

Whipple disease is a systemic illness resulting from bacterial infection by a rare species of bacilli, Tropheryma whippleii. The gastrointestinal tract is the most frequently affected organ although the disease can spread to joints, central nervous system, eyes and rarely, heart. The disease is clinically presented with gastrointestinal symptoms (diarrhea, abdominal pain, loss of appetite. Whipple disease is a chronic, relapsing, and multisystem disease. It presents a diagnostic challenge for both clinicians and pathologists. Recent advances in isolation and culture have identified the organism responsible for the disease to be a member of the order Actinomycetes designated Tropheryma whipplei Whipple's disease is caused by a specific type of bacteria. It causes abnormal changes on the wall of the small intestine. These changes disrupt the villi. Villi are tiny, finger-like structures that stick out from the wall of the intestine to help absorb nutrients Whipple's Disease is a chronic, relapsing multisystem disease first described by George Hoyt Whipple. Understand Whipple's Disease

Whipple's disease - wikidoc

Whipple disease interferes with normal digestion by impairing the breakdown of foods, such as fats and carbohydrates, and hampering your body's ability to absorb nutrients. Whipple disease can also infect other organs, including your brain, heart and eyes. Without proper treatment, Whipple disease can be serious or fatal Whipple's disease are various and nonspecific. Arthralgias have been reported in 75% of patients, involving periph-eral joints. These arthralgias are migratory and neither destructive nor deforming [7,30]. Thus, the diagnosis of rheumatic disease is frequently suggested before diagnosis with Whipple's disease. At diagnosis, weight loss. Whipple disease, a rare sporadic disease, was first considered a metabolic disease (1) and later suspected to be an infectious disease caused by a rare bacterium, Tropheryma whipplei (2). Intrafamilial Circulation of Tropheryma whipplei, Franc

La enfermedad de Whipple es una enfermedad bacteriana infecciosa que afecta muchos órganos del cuerpo e interfiere con la capacidad del cuerpo para metabolizar las grasas. La enfermedad, por lo general, afecta el sistema gastrointestinal, pero puede afectar cualquier parte del cuerpo incluyendo el corazón, los pulmones, el cerebro, las articulaciones, y los ojos Whipple Disease Due to the National Reconfiguration of Genomic Services, this laboratory will no longer be offering testing for Whipple disease from 21/05//2018. For further information, please refer to the letter for users Whipple disease, which is caused by infection with Tropheryma whipplei, can be treated effectively with antimicrobials. Occasionally, inflammation reappears after initial improvement; this is. Background. Whipple disease is a systemic disease most likely caused by a gram-positive bacterium, Tropheryma whipplei (formerly T whippelii). [1, 2] Although the first descriptions of the disorder described a malabsorption syndrome with small intestine involvement, the disease also affects the joints, central nervous system, and cardiovascular system Whipple disease: A form of inability to absorb nutrients from the intestine. It can affect any part of the body, leading to arthritis and then weight loss, cough, fever, diarrhea, hypotension (low blood pressure), abdominal swelling, increased skin pigmentation, and severe anemia.Whipple disease has been discovered to be due to a type of bacteria named Tropheryma whippelii

Diarrhea and inadequate nutrient absorption (malabsorption) can have various causes. In rare cases it can be due to Whipple's disease.In addition to the small intestine, a general infection affects various other organ systems. It is believed that infection with the pathogen Tropheryma whipplei causes the systemic disease. Due to the damage to the small intestine, the disease leads to diarrhea. Whipple's Disease is considered infectious but is not transmitted from person to person. Generally, a disease like this is caused by an infectious agent and not spread between people. Whipple's Disease, although infectious, is not a genetic disease Whipple disease is extremely rare worldwide; only several hundred clinical cases have been reported, mostly from North America and Western Europe. The disease appears to be associated with the. Introduction. Whipple's disease is a rare chronic infection first described in 1907. The causative agent is the intracellular Gram-positive bacterium Tropheryma whipplei, which was identified by molecular sequencing in 1992[].This ubiquitous commensal organism very rarely causes disease

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